https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The genetic architecture of the human cerebral cortex https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42676 Wed 22 Mar 2023 14:34:07 AEDT ]]> Virtual Ontogeny of Cortical Growth Preceding Mental Illness https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51029 Wed 16 Aug 2023 10:09:44 AEST ]]> Genetic effects on the timing of parturition and links to fetal birth weight https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52463 Wed 11 Oct 2023 15:07:44 AEDT ]]> Association of Structural Magnetic Resonance Imaging Measures with Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49020 Wed 03 May 2023 12:31:22 AEST ]]> Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49007 Wed 03 May 2023 12:17:36 AEST ]]> Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44746 Tue 21 Mar 2023 16:53:58 AEDT ]]> Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41379 Tue 04 Apr 2023 19:08:51 AEST ]]> Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50952 overall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (|rg| > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range |rg| = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa. Conclusion: Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.]]> Mon 14 Aug 2023 14:36:09 AEST ]]> Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49142 Fri 05 May 2023 12:07:01 AEST ]]> Beyond the Global Brain Differences: Intra-individual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54564 Fri 01 Mar 2024 11:18:59 AEDT ]]>